Abstract
The "case-control" research in Russian Altai territory population has proved that DR15 and DR3 as well as the combination of female sex and alleles A of TNFα of rs1800629 locus are associated with high risk of multiple sclerosis. The relationship between disease and CD40 polymorphism (rs6074022) was not found.
MeSH terms
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Adult
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Alleles
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CD40 Antigens / genetics
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Female
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HLA-DR Antigens / genetics*
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HLA-DRB1 Chains
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Humans
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Male
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Middle Aged
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Multiple Sclerosis / epidemiology*
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Multiple Sclerosis / genetics*
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Polymorphism, Genetic
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Risk Factors
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Siberia / epidemiology
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Tumor Necrosis Factor-alpha / genetics*
Substances
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CD40 Antigens
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HLA-DR Antigens
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HLA-DRB1 Chains
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Tumor Necrosis Factor-alpha