Abstract
A new triterpenoid, 4,4,14α-trimethyl-5α-chol-7,9(11)-dien-3-oxo-24-oic acid (1), together with seven known triterpenoids, were isolated from the dried fruiting bodies of Ganoderma lucidum. Their structures were elucidated by extensive spectroscopic analyses. Bioassay results revealed that compounds 1 and methyl ganoderic acid B (5) had nerve growth factor-like neuronal survival-promoting effects, whereas compounds 1, and 4-7 showed brain-derived neurotrophic factor-like neuronal survival-promoting activities.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Biological Assay
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Cell Survival / drug effects
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China
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Fruit / chemistry*
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Lanosterol / analysis
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Lanosterol / chemistry
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Lanosterol / isolation & purification*
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Lanosterol / pharmacology*
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Mice
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Molecular Structure
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NIH 3T3 Cells
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Nerve Growth Factors / chemistry
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Nerve Growth Factors / pharmacology
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Neurons / drug effects*
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Polysaccharides / pharmacology
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Reishi / chemistry*
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Spectrum Analysis
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Sterols / pharmacology
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Triterpenes / analysis
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Triterpenes / chemistry
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Triterpenes / isolation & purification*
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Triterpenes / pharmacology*
Substances
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Nerve Growth Factors
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Polysaccharides
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Sterols
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Triterpenes
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Lanosterol
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ganoderic acid B