Abstract
Hydrolytically-labile hydrazones in peptide amphiphiles were studied as degradable tethers for release of the drug nabumetone from nanofiber gels. On-resin addition of the novel compound tri-Boc-hydrazido adipic acid to a lysine ε-amine allowed for precise placement of a hydrazide in a peptide sequence.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Drug Carriers / chemistry*
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Gels
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Hydrazones / chemistry*
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Hydrolysis
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Hydrophobic and Hydrophilic Interactions*
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Peptides / chemistry*
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Solubility
Substances
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Drug Carriers
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Gels
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Hydrazones
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Peptides