Abstract
The genetic characteristics of mumps virus (MuV) strains isolated from sporadic mumps cases between 2007 and 2009 in three provinces of south-west China were investigated. MuV detection was carried out by nested RT-PCR on 117 cases. The small hydrophobic gene of 33 isolated strains was identified, and sequence analysis revealed that all the isolates belonged to the lineage genotype F with slight nucleotide variation. Furthermore, the virus haemagglutinin-neuraminidase and nucleoprotein antigens exhibited a high degree of nucleotide and amino acid similarity (>99 %) within all isolates, whilst the fusion protein appeared to have certain geographical differences. This study on molecular surveillance will help to monitor the circulation of MuV in China.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Child
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Child, Preschool
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China / epidemiology
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Cluster Analysis
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Female
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Humans
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Male
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Molecular Epidemiology
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Molecular Sequence Data
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Mumps / epidemiology*
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Mumps / virology*
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Mumps virus / classification*
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Mumps virus / genetics*
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Mumps virus / isolation & purification
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Phylogeography
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Polymerase Chain Reaction
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RNA, Viral / genetics
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Reverse Transcriptase Polymerase Chain Reaction
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Sequence Analysis, DNA
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Viral Proteins / genetics
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Young Adult
Substances
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RNA, Viral
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Viral Proteins
Associated data
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GENBANK/GQ501072
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GENBANK/GQ501073
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GENBANK/GQ501074
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GENBANK/GQ501075
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GENBANK/GQ501076
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GENBANK/GQ501077
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GENBANK/GQ501078
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GENBANK/GQ501079
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GENBANK/GQ501080
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GENBANK/GQ501081
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GENBANK/GQ501082
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GENBANK/GQ501083
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GENBANK/GQ501084
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GENBANK/GQ501085
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GENBANK/GQ501086
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GENBANK/GQ501087
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GENBANK/GQ501088
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GENBANK/HQ171942
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GENBANK/HQ171943
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GENBANK/HQ171944
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GENBANK/HQ171945
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GENBANK/HQ171946
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GENBANK/HQ171968