Synthesis of substituted pyrazoles via tandem cross-coupling/electrocyclization of enol triflates and diazoacetates

J Org Chem. 2011 Aug 5;76(15):5915-23. doi: 10.1021/jo201042c. Epub 2011 Jun 27.

Abstract

The synthesis of 3,4,5-trisubstituted pyrazoles via a tandem catalytic cross-coupling/electrocyclization of enol triflates and diazoacetates is presented. The initial scope of this methodology is demonstrated on a range of differentially substituted acyclic and cyclic enol triflates as well as an elaborated set of diazoacetates to provide the corresponding pyrazoles with a high degree of structural complexity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Cross-Linking Reagents / chemistry
  • Cyclization
  • Diazonium Compounds / chemistry*
  • Molecular Structure
  • Pyrazoles / chemical synthesis*
  • Pyrazoles / chemistry*
  • Stereoisomerism

Substances

  • Cross-Linking Reagents
  • Diazonium Compounds
  • Pyrazoles