Abstract
Small Rho family GTPases are important regulators of cellular traffic. Emerging evidence now implicates Rac1 and Rac-dependent actin reorganisation in insulin-induced recruitment of glucose transporter-4 (GLUT4) to the cell surface of muscle cells and mature skeletal muscle. This review summarises the current thinking on the regulation of Rac1 by insulin, the role of Rac-dependent cortical actin remodelling in GLUT4 traffic, and the impact of Rac1 towards insulin resistance in skeletal muscle.
Copyright © 2011 Elsevier Inc. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Actins / metabolism
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Animals
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GTPase-Activating Proteins / metabolism
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Glucose / metabolism
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Glucose Transporter Type 4 / metabolism*
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Guanine Nucleotide Dissociation Inhibitors / metabolism
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Humans
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Insulin / metabolism*
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Insulin Resistance
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Muscle Cells / metabolism
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Muscle, Skeletal / metabolism*
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Phosphorylation
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Protein Transport
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Signal Transduction*
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rac1 GTP-Binding Protein / metabolism*
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rho-Specific Guanine Nucleotide Dissociation Inhibitors
Substances
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Actins
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GTPase-Activating Proteins
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Glucose Transporter Type 4
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Guanine Nucleotide Dissociation Inhibitors
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Insulin
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RAC1 protein, human
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SLC2A4 protein, human
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rho-Specific Guanine Nucleotide Dissociation Inhibitors
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rac1 GTP-Binding Protein
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Glucose