Resveratrol enhances the expression of death receptor Fas/CD95 and induces differentiation and apoptosis in anaplastic large-cell lymphoma cells

Ya-Chen Ko; Chia-Ling Chang; Hsiung-Fei Chien; Ching-Hsiang Wu; Liang-In Lin

doi:10.1016/j.canlet.2011.05.014

Resveratrol enhances the expression of death receptor Fas/CD95 and induces differentiation and apoptosis in anaplastic large-cell lymphoma cells

Cancer Lett. 2011 Oct 1;309(1):46-53. doi: 10.1016/j.canlet.2011.05.014. Epub 2011 Jun 17.

Authors

Ya-Chen Ko¹, Chia-Ling Chang, Hsiung-Fei Chien, Ching-Hsiang Wu, Liang-In Lin

Affiliation

¹ Department of Radiological Technology, Yuanpei University, Hsinchu, Taiwan.

PMID: 21683516
DOI: 10.1016/j.canlet.2011.05.014

Abstract

Resveratrol (3,5,4'-trihydroxy-trans-stilbene), a phytoalexin found in grapes and other plants, plays a protective role in human atherosclerosis and carcinogenesis. We examined the effects of resveratrol on the anaplastic large-cell lymphoma (ALCL) cell line SR-786. Resveratrol inhibited growth and induced cellular differentiation, as demonstrated by morphological changes and elevated expression of T cell differentiation markers CD2, CD3, and CD8. Resveratrol also triggered cellular apoptosis, as demonstrated by morphological observations, DNA fragmentation, and cell cycle analyses. Further, the surface expression of the death receptor Fas/CD95 was increased by resveratrol treatment. Our data suggest that resveratrol may have potential therapeutic value for ALCL.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anticarcinogenic Agents / pharmacology*
Apoptosis / drug effects
Cell Cycle / drug effects
Cell Differentiation / drug effects
Cell Line, Tumor
DNA Fragmentation / drug effects
Humans
Lymphoma, Large-Cell, Anaplastic* / drug therapy
Lymphoma, Large-Cell, Anaplastic* / metabolism
Lymphoma, Large-Cell, Anaplastic* / pathology
Resveratrol
Stilbenes / pharmacology*
fas Receptor / metabolism*

Substances

Anticarcinogenic Agents
Stilbenes
fas Receptor
Resveratrol