The putative visual word form area is functionally connected to the dorsal attention network

Cereb Cortex. 2012 Mar;22(3):537-49. doi: 10.1093/cercor/bhr100. Epub 2011 Jun 20.

Abstract

The putative visual word form area (pVWFA) is the most consistently activated region in single word reading studies (i.e., Vigneau et al. 2006), yet its function remains a matter of debate. The pVWFA may be predominantly used in reading or it could be a more general visual processor used in reading but also in other visual tasks. Here, resting-state functional connectivity magnetic resonance imaging (rs-fcMRI) is used to characterize the functional relationships of the pVWFA to help adjudicate between these possibilities. rs-fcMRI defines relationships based on correlations in slow fluctuations of blood oxygen level-dependent activity occurring at rest. In this study, rs-fcMRI correlations show little relationship between the pVWFA and reading-related regions but a strong relationship between the pVWFA and dorsal attention regions thought to be related to spatial and feature attention. The rs-fcMRI correlations between the pVWFA and regions of the dorsal attention network increase with age and reading skill, while the correlations between the pVWFA and reading-related regions do not. These results argue the pVWFA is not used predominantly in reading but is a more general visual processor used in other visual tasks, as well as reading.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Attention / physiology*
  • Cerebral Cortex / physiology*
  • Child
  • Female
  • Humans
  • Male
  • Nerve Net / physiology*
  • Pattern Recognition, Visual / physiology*
  • Photic Stimulation / methods
  • Reading*
  • Semantics
  • Verbal Behavior / physiology
  • Young Adult