The role of anti-HLA antibodies in hematopoietic stem cell transplantation

Biol Blood Marrow Transplant. 2011 Nov;17(11):1585-8. doi: 10.1016/j.bbmt.2011.06.004. Epub 2011 Jun 16.

Abstract

Donor-specific antihuman leukocyte antigen antibodies (DSHA) have been clearly implicated in graft rejection in solid organ transplantation. Their role in allogeneic hematopoietic stem-cell transplantation (allo-HSCT) remains unclear. We summarize here evidence supporting a role for DSHA in graft failure in animal models of allo-HSCT and in clinical settings whenever no full HLA matching occurs.

Publication types

  • Review

MeSH terms

  • Animals
  • Autoantibodies / immunology*
  • Disease Models, Animal
  • Graft Rejection / immunology*
  • HLA Antigens / immunology*
  • Hematopoietic Stem Cell Transplantation / adverse effects
  • Hematopoietic Stem Cell Transplantation / methods*
  • Humans

Substances

  • Autoantibodies
  • HLA Antigens