During a one year period, central nervous system (CNS) lesions were diagnosed by transfontanella cranial sonography (TCS) in 46 infants at the university medical centre of Yaoundé, Cameroun. The most frequent features were hydrocephaly (22 cases) and perinatal vascular pathology (17 cases). Because of its very low cost/efficacy ratio TCS should be more largely used in the African hospitals for the diagnosis of brain damages in infants.