Genomic organization of the transposable element Tdd-3 from Dictyostelium discoideum

Nucleic Acids Res. 1990 Oct 11;18(19):5751-7. doi: 10.1093/nar/18.19.5751.

Abstract

The transposable element Tdd-3 from D. discoideum has been described originally in 1984 (Poole and Firtel, 1984). Additional copies of this element were discovered in the course of a recent study on tRNA gene organization in D. discoideum. Five out of 24 independently isolated tRNA genes proved to be associated with Tdd-3 elements. The surprising observation that all the elements always occurred within the 3'-flanking sequences of the Dictyostelium tRNA genes suggested the possibility of a general position specific integration of Tdd-3 elements upon transposition. Therefore we isolated additional Tdd-3 elements from various genomic D. discoideum libraries in order to test this hypothesis. Several new Tdd-3 elements were found associated with various tRNA genes. Additionally we identified Tdd-3 elements organized in tandem array or in association with RED (Repetitive Element of Dictyostelium), another repetitive element recently identified by our laboratory. In all cases a B-box equivalent of the eukaryotic gene-internal RNA polymerase III promoter was identified upstream of all Tdd-3 elements.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Blotting, Southern
  • Cloning, Molecular
  • DNA Transposable Elements*
  • Dictyostelium / genetics*
  • Genes, Fungal
  • Molecular Sequence Data
  • RNA, Fungal / genetics
  • RNA, Transfer / genetics*
  • Restriction Mapping

Substances

  • DNA Transposable Elements
  • RNA, Fungal
  • RNA, Transfer

Associated data

  • GENBANK/X53437
  • GENBANK/X53438