62 patients with acute pancreatitis (AP) were examined in order to determine hemocoagulation disorders. The obtained results showed that the patients developed the consumptive coagulopathy with high levels of D-dimer, activation and exhaustion of antithrombin III (AT III). The development of hemocoagulation disturbances in patients with severe AP was confirmed through decrease of activity of AT III up to 68% and high level of D-dimer>693 ng/ml.