Abstract
An operationally simple method for the synthesis of peptide thioesters is developed using standard Fmoc solid-phase peptide synthesis procedures. The method relies on the use of a premade enamide-containing amino acid which, in the final TFA cleavage step, renders the desired thioester functionality through an irreversible intramolecular N-to-S acyl transfer.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Amino Acid Sequence
-
Amino Acids / chemical synthesis
-
Amino Acids / chemistry
-
Carrier Proteins / chemical synthesis
-
Chemistry, Organic / methods*
-
Copper Transport Proteins
-
Esters / chemical synthesis
-
Esters / chemistry
-
Humans
-
Molecular Sequence Data
-
Peptides / chemical synthesis*
-
Peptides / chemistry
-
Sulfhydryl Compounds / chemical synthesis*
-
Sulfhydryl Compounds / chemistry
Substances
-
Amino Acids
-
COX17 protein, human
-
Carrier Proteins
-
Copper Transport Proteins
-
Esters
-
Peptides
-
Sulfhydryl Compounds