Topical application of two condensed tannins from the root of Rosa multiflora Thunberg for the treatment of atopic dermatitis (AD) in NC/Nga mice

Phytother Res. 2011 Oct;25(10):1564-9. doi: 10.1002/ptr.3578. Epub 2011 Jun 30.

Abstract

Recently, the isolation of several condensed tannins from the roots of Rosa multiflora Thunberg, a traditional herbal therapy in oriental medicine for rheumatoid arthritis and scabies, was described. Two of the major condensed tannins - procyanidin B-3 (ProB3) and ent-guibourtinidol-(4β → 6)-catechin (RM-1) - were then applied topically to atopic dermatitis-like skin lesions on NC/Nga mice in order to assess their immunomodulatory properties. Both ProB3 and RM-1 significantly reduced the serum levels of eosinophils, IgE and certain Th2 cytokines (IL-4, 5 and 13) (p < 0.05 or 0.01). Additionally, ProB3 and RM-1 significantly reduced both the mRNA and protein expression of COX-2 and iNOS in mouse skin tissues (p < 0.01). Such results strongly suggest that ProB3 and RM-1 may be useful in the treatment allergic skin conditions, most notably atopic dermatitis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Topical
  • Animals
  • Biflavonoids / pharmacology
  • Biflavonoids / therapeutic use*
  • Catechin / analogs & derivatives
  • Catechin / pharmacology
  • Catechin / therapeutic use*
  • Cyclooxygenase Inhibitors / pharmacology
  • Cyclooxygenase Inhibitors / therapeutic use
  • Cytokines / blood
  • Dermatitis, Atopic / drug therapy*
  • Dermatitis, Atopic / immunology
  • Dermatitis, Atopic / metabolism
  • Eosinophils / metabolism
  • Female
  • Immunoglobulin E / blood
  • Immunologic Factors / pharmacology*
  • Immunologic Factors / therapeutic use
  • Mice
  • Mice, Inbred Strains
  • Nitric Oxide Synthase Type II / metabolism
  • Phytotherapy*
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use*
  • Plant Roots
  • Proanthocyanidins / pharmacology
  • Proanthocyanidins / therapeutic use*
  • RNA, Messenger / metabolism
  • Rosa / chemistry*
  • Skin / drug effects
  • Skin / immunology
  • Skin / pathology
  • Th2 Cells / metabolism

Substances

  • Biflavonoids
  • Cyclooxygenase Inhibitors
  • Cytokines
  • Immunologic Factors
  • Plant Extracts
  • Proanthocyanidins
  • RNA, Messenger
  • procyanidin B3
  • Immunoglobulin E
  • Catechin
  • Nitric Oxide Synthase Type II