Abstract
Earlier unknown 1,8-diamino-3-methyl-4-azaoctane (gamma-MeSpd) was synthesized. The analogue was not a substrate of ether spermine/spermidine N1-acetyltransferase, or spermine synthase, but was capable to support the growth of DU145 cells with depleted polyamine pool. Such a combination of y-MeSpd properties discloses novel opportunities to study cellular functions of catabolically unstable and easily interconvertible spermine and spermidine.
MeSH terms
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Acetyltransferases / metabolism
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Biomimetic Materials / chemical synthesis*
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Cell Growth Processes / drug effects
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Cell Line, Tumor
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Humans
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Male
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Prostatic Neoplasms / metabolism*
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Prostatic Neoplasms / pathology
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Protein Stability*
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Spermidine / analogs & derivatives
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Spermidine / chemical synthesis*
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Spermidine / metabolism
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Spermidine / pharmacology
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Spermine / metabolism*
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Spermine Synthase / metabolism
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Substrate Specificity
Substances
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1,8-diamino-3-methyl-4-azaoctane
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Spermine
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Acetyltransferases
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diamine N-acetyltransferase
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Spermine Synthase
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Spermidine