The contractile effect of tachykinins on human prostatic urethra: involvement of NK-2 receptors

J Urol. 1990 Dec;144(6):1543-5. doi: 10.1016/s0022-5347(17)39795-1.

Abstract

The contractile response to natural tachykinins [substance P (SP), neurokinin A (NKA), arginin-neurokinin B (ArgNKB)] and to synthetic peptide [Pro9]SP sulfone, [beta Ala8]NKA(4-10) and [MePhe7]NKB, were investigated in the isolated smooth muscle from the human prostatic urethra. Natural tachykinins evoked concentration-related responses with the following order of potency: NKA----NKB--------SP. Among selective agonists [beta Ala8]NKA(4-10) produced concentration-related contractions, while [Pro9]SP sulfone and [MePhe7]NKB were inactive. These data indicate the presence of NK-2 receptors in the smooth muscle of the human prostatic urethra.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Humans
  • In Vitro Techniques
  • Male
  • Middle Aged
  • Muscle Contraction / drug effects*
  • Muscle, Smooth / drug effects
  • Muscle, Smooth / physiology*
  • Receptors, Neurotransmitter / drug effects
  • Receptors, Neurotransmitter / physiology*
  • Receptors, Tachykinin
  • Tachykinins / pharmacology*
  • Urethra / drug effects*
  • Urethra / physiology

Substances

  • Receptors, Neurotransmitter
  • Receptors, Tachykinin
  • Tachykinins