Antitumor activities and interaction with DNA of oxaliplatin-type platinum complexes with linear or branched alkoxyacetates as leaving groups

Runting Yin; Shaohua Gou; Xia Liu; Liguang Lou

doi:10.1016/j.jinorgbio.2011.05.005

Antitumor activities and interaction with DNA of oxaliplatin-type platinum complexes with linear or branched alkoxyacetates as leaving groups

J Inorg Biochem. 2011 Aug;105(8):1095-101. doi: 10.1016/j.jinorgbio.2011.05.005. Epub 2011 May 19.

Authors

Runting Yin¹, Shaohua Gou, Xia Liu, Liguang Lou

Affiliation

¹ Jiangsu Province Hi-Tech Key Laboratory for Bio-medical Research, Pharmaceutical Research Center, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, PR China.

PMID: 21726773
DOI: 10.1016/j.jinorgbio.2011.05.005

Abstract

Five oxaliplatin-typed platinum complexes containing trans-1R, 2R-diaminocyclohexane chelating platinum cores, characteristic of linear or branched alkoxycarboxylates as leaving groups, were biologically evaluated. These compounds showed higher antitumor activity, lower toxicity in vivo than cisplatin or oxaliplatin. And the results revealed that the antitumor activity and interaction with DNA of these compounds were highly related to the nature of leaving groups. Among these complexes, 5a, cis-(trans-1R, 2R-diaminocyclohexane) bis (2-tert-butoxyacetate) platinum(II), showed the highest antitumor activity and the lowest toxicity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / chemistry*
Antineoplastic Agents / toxicity*
Apoptosis
DNA / chemistry*
DNA / metabolism
Female
Humans
Mice
Mice, Inbred C57BL
Mice, Nude
Organoplatinum Compounds / chemistry*
Organoplatinum Compounds / toxicity*
Oxaliplatin
Structure-Activity Relationship
Tumor Cells, Cultured

Substances

(diaminocyclohexane)bis(2-tert-butoxyacetate)platinum(II)
Antineoplastic Agents
Organoplatinum Compounds
Oxaliplatin
DNA