Reversible acetylation of metabolic enzymes celebration: SIRT2 and p300 join the party

Jiyung Shin; Dan Zhang; Danica Chen

doi:10.1016/j.molcel.2011.06.010

Reversible acetylation of metabolic enzymes celebration: SIRT2 and p300 join the party

Mol Cell. 2011 Jul 8;43(1):3-5. doi: 10.1016/j.molcel.2011.06.010.

Authors

Jiyung Shin¹, Dan Zhang, Danica Chen

Affiliation

¹ Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA.

PMID: 21726804
DOI: 10.1016/j.molcel.2011.06.010

Abstract

Compelling evidence suggests that metabolic pathways are coordinated through reversible acetylation of metabolic enzymes in response to nutrient availability. In this issue of Molecular Cell, Jiang et al. (2011) show that the rate-limiting enzyme in gluconeogenesis, phosphoenolpyruvate carboxykinase 1, is regulated through reversible acetylation by SIRT2 and p300.

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