Synthesis and Suzuki-Miyaura cross-coupling reactions of potassium Boc-protected aminomethyltrifluoroborate with aryl and hetaryl halides

Org Lett. 2011 Aug 5;13(15):3956-9. doi: 10.1021/ol2014768. Epub 2011 Jul 6.

Abstract

Potassium Boc-protected aminomethyltrifluoroborate, a primary aminomethyl equivalent, was synthesized successfully through a "one-pot" process. With this trifluoroborate, Suzuki-Miyaura cross-coupling reactions were investigated with a variety of both aryl and hetaryl chlorides in good to excellent yields.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Amination
  • Boric Acids / chemical synthesis*
  • Dimerization
  • Fluorine / chemistry*
  • Formic Acid Esters / chemistry*
  • Halogens / chemistry*
  • Methylation
  • Molecular Structure
  • Potassium / chemistry*

Substances

  • Boric Acids
  • Formic Acid Esters
  • Halogens
  • t-butyloxycarbonyl group
  • Fluorine
  • boric acid
  • Potassium