Abstract
Nine new compounds were synthesized and tested for their alpha-adrenoceptor affinity and antihypertensive activity together with 5 other previously reported compounds. Compounds I, IIa, IIb and IIIa showed high alpha-adrenoceptor affinity and strong antihypertensive activity.
MeSH terms
-
Animals
-
Antihypertensive Agents*
-
Blood Pressure / drug effects*
-
Ethylamines / chemical synthesis*
-
Ethylamines / pharmacology
-
Mexiletine / analogs & derivatives*
-
Mexiletine / chemical synthesis
-
Mexiletine / pharmacology
-
Rats
-
Receptors, Adrenergic, alpha / metabolism
Substances
-
Antihypertensive Agents
-
Ethylamines
-
Receptors, Adrenergic, alpha
-
Mexiletine