Abstract
DC-SIGN and Langerin are two C-type lectins involved in the initial steps of HIV infections: the former acts as a viral attachment factor and facilitates viral invasion of the immune system, the latter has a protective effect. Potential antiviral compounds targeted against DC-SIGN were synthesized using a common fucosylamide anchor. Their DC-SIGN affinity was tested by SPR and found to be similar to that of the natural ligand Lewis-X (Le(X)). The compounds were also found to be selective for DC-SIGN and to interact only weakly with Langerin. These molecules are potentially useful therapeutic tools against sexually transmitted HIV infection.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-HIV Agents / chemistry
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Anti-HIV Agents / pharmacology
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Antigens, CD / metabolism
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Cell Adhesion Molecules / antagonists & inhibitors*
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Cell Adhesion Molecules / metabolism*
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Fucose / chemistry*
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Fucose / pharmacology*
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HIV Infections / drug therapy
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Humans
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Lectins, C-Type / antagonists & inhibitors*
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Lectins, C-Type / metabolism*
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Mannose-Binding Lectins / metabolism
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Models, Molecular
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Protein Binding
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Receptors, Cell Surface / antagonists & inhibitors*
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Receptors, Cell Surface / metabolism*
Substances
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Anti-HIV Agents
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Antigens, CD
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CD207 protein, human
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Cell Adhesion Molecules
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DC-specific ICAM-3 grabbing nonintegrin
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Lectins, C-Type
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Mannose-Binding Lectins
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Receptors, Cell Surface
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Fucose