Abstract
A new β-amino acrylic acid Ni(II) complex has been developed and used for the synthesis of α-alkyl-β-amino acids via alkylation with alkyl halides under operationally convenient conditions. The pivotal α-alkylated intermediate can be converted into the corresponding α-alkyl-β-amino acids via two steps with a wide range of substituents.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkylation
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Amino Acids / chemical synthesis*
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Amino Acids / chemistry
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Catalysis
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Glycine / chemistry*
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Nickel / chemistry*
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Organometallic Compounds / chemistry*
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Stereoisomerism
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beta-Alanine / chemistry*
Substances
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Amino Acids
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Organometallic Compounds
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beta-Alanine
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Nickel
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Glycine