Glycine enhances [3H]noradrenaline release from slices of rat hippocampus

Neurosci Lett. 1990 Aug 24;116(3):352-6. doi: 10.1016/0304-3940(90)90100-n.

Abstract

The effects of glycine on the release of [3H]noradrenaline ([3H]NA) have been investigated using rat hippocampus slices previously labeled with the radioactive catecholamine. Glycine (30-1000 microM) produced a potent and concentration-dependent increase of the release of [3H]NA evoked by 12 mM KCl. The effect of 1000 microM glycine was totally antagonized by 3 microM strychnine suggesting that, in rat hippocampus, glycine may regulate the release of NA by activating a receptor of the strychnine-sensitive subtype.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Glycine / antagonists & inhibitors
  • Glycine / pharmacology*
  • Hippocampus / metabolism*
  • In Vitro Techniques
  • Male
  • Norepinephrine / metabolism*
  • Potassium Chloride / pharmacology
  • Rats
  • Rats, Inbred Strains
  • Receptors, Cell Surface / drug effects
  • Receptors, Cell Surface / physiology
  • Strychnine / pharmacology
  • Time Factors
  • Tritium

Substances

  • Receptors, Cell Surface
  • Tritium
  • Potassium Chloride
  • Strychnine
  • Glycine
  • Norepinephrine