Abstract
Cdk5 (cyclin-dependent kinase 5 or initially NCLK for neuronal CDC2-like kinase) was switched twice at its birth nearly twenty years ago: first it was thought to be cyclin-dependent, second it was assumed to be primarily of importance in neuronal cells-both turned out not to be the case. In this review we want to discuss issues of pharmacological inhibition, to highlight the versatile roles, and to summarize the growing evidence for the functional importance of Cdk5 in non-neuronal tissues, such as blood cells, tumor cells, epithelial cells, the vascular endothelium, testis, adipose and endocrine tissues. The organizing principles we follow are apoptosis/cell death, migration/motility, aspects of inflammation, and, finally, secretion/metabolism.
Copyright © 2011 Elsevier Inc. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Apoptosis / drug effects
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Cell Movement / drug effects
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Cell Proliferation / drug effects
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Cyclin-Dependent Kinase 5* / physiology
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Endothelial Cells / cytology
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Endothelial Cells / metabolism*
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Epithelial Cells / cytology
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Epithelial Cells / metabolism*
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Gene Expression Regulation / physiology*
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Humans
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Inflammation / genetics
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Inflammation / immunology
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Lymphocyte Activation / genetics
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Lymphocyte Activation / immunology
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Mice
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Mice, Transgenic
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NF-kappa B / genetics
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NF-kappa B / metabolism
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Neovascularization, Physiologic / genetics
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Neuroglia / cytology
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Neuroglia / metabolism
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Neurons / cytology
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Neurons / metabolism
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Nociception / physiology*
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Organ Specificity / genetics
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Protein Kinase Inhibitors / pharmacology
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Purines / pharmacology
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Roscovitine
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Signal Transduction / drug effects
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Signal Transduction / genetics*
Substances
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NF-kappa B
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Protein Kinase Inhibitors
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Purines
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Roscovitine
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Cyclin-Dependent Kinase 5