Padanamides A and B, highly modified linear tetrapeptides produced in culture by a Streptomyces sp. isolated from a marine sediment

Org Lett. 2011 Aug 5;13(15):3936-9. doi: 10.1021/ol2014494. Epub 2011 Jul 12.

Abstract

Two highly modified linear tetrapeptides, padanamides A (1) and B (2), are produced by laboratory cultures of a Streptomyces sp. obtained from a marine sediment. Padanamide B is cytotoxic to Jurkat cells, and a chemical genomics analysis using Saccharomyces cerevisiae deletion mutants suggested that padanamide A inhibits cysteine and methionine biosynthesis or that these amino acids are involved in the yeast's response to the peptide.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Cell Survival / drug effects
  • Geologic Sediments / microbiology*
  • Humans
  • Jurkat Cells
  • Models, Molecular
  • Molecular Structure
  • Oligopeptides / biosynthesis
  • Oligopeptides / chemistry*
  • Oligopeptides / pharmacology
  • Saccharomyces cerevisiae / chemistry
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / metabolism
  • Streptomyces / chemistry*
  • Streptomyces / isolation & purification

Substances

  • Oligopeptides
  • padanamide A
  • padanamide B