Abstract
Macrolide resistance in Mycoplasma pneumoniae is often found in Asia but is rare elsewhere. We report the emergence of macrolide-resistant M. pneumoniae in Israel and the in vivo evolution of such resistance during the treatment of a 6-year-old boy with pneumonia.
MeSH terms
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Adolescent
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Adult
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Anti-Bacterial Agents / pharmacology*
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Anti-Bacterial Agents / therapeutic use
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Base Sequence
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Child
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Child, Preschool
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Drug Resistance, Bacterial*
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Female
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Gene Expression Regulation, Bacterial / drug effects
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Humans
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Infant
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Infant, Newborn
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Israel
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Macrolides / pharmacology*
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Macrolides / therapeutic use
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Male
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Mutation / genetics
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Mycoplasma pneumoniae / drug effects*
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Mycoplasma pneumoniae / genetics
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Mycoplasma pneumoniae / isolation & purification
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Pneumonia, Mycoplasma / diagnosis*
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Pneumonia, Mycoplasma / drug therapy
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Pneumonia, Mycoplasma / microbiology*
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RNA, Ribosomal, 23S / genetics
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Young Adult
Substances
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Anti-Bacterial Agents
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Macrolides
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RNA, Ribosomal, 23S