Penile cysts are uncommon lesions. In general, they are asymptomatic and do not interfere with sexual function. Most of them are present since birth, but usually they are only detectable in adolescence or adulthood. We report a rare case of a young adult man with a 5 × 5-cm nodule on the prepuce (ventral face), which appeared 2 years ago and interfered with his sexual function. The nodule was excised by circumcision and a histopathologic study was performed. Histopathologic examination revealed a mucoid cyst of penis with epidermoid metaplasia. No recurrence was observed at a 6 months follow-up and the patient's sexual function returned to normal.