Abstract
A new sesquiterpenoid, namely Linerenone (1), together with three known sesquiterpenoids (2-4), were isolated from the fruits of Lindera communis. Their structures were determined by extensive spectroscopic analysis including 1D, 2D-NMR and HR-MS spectra. Compound 1 showed significant cytotoxic activity against H460, ES2 and DU145 cancer cells with IC(50) of 2.1 μg/mL, 2.8 μg/mL and 3.0 μg/mL, respectively.
Crown Copyright © 2011. Published by Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology
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Antineoplastic Agents, Phytogenic / therapeutic use*
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Cell Line, Tumor
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Fruit
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Humans
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Lindera / chemistry*
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Molecular Structure
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Neoplasms / drug therapy*
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Phytotherapy*
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
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Plant Extracts / therapeutic use*
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Sesquiterpenes / isolation & purification
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Sesquiterpenes / pharmacology
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Sesquiterpenes / therapeutic use*
Substances
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Antineoplastic Agents, Phytogenic
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Plant Extracts
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Sesquiterpenes
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linerenone