Post-exposure prophylaxis for H1N1 with oseltamivir in renal allograft recipient--safe and effective without any immunosuppresive drug interaction

Vivek Kute; K R Goplani; S M Godara; P R Shah; A V Vanikar; H L Trivedii

Post-exposure prophylaxis for H1N1 with oseltamivir in renal allograft recipient--safe and effective without any immunosuppresive drug interaction

J Assoc Physicians India. 2011 Jan:59:49-51.

Authors

Vivek Kute¹, K R Goplani, S M Godara, P R Shah, A V Vanikar, H L Trivedii

Affiliation

¹ Department of Nephrology and Clinical Transplantation, Dr H L Trivedi Institute of Transplantation Sciences (ITS) Ahmedabad 380016, Gujarat, India.

PMID: 21751666

Abstract

Kidney transplant recipients are at a high risk for H1N1 infection associated complications during the current pandemic. Prevention of infection by immunization, together with early recognition and prompt antiviral treatment are critical. Post-exposure prophylaxis of H1N1 with oseltamivir was safe, effective and well tolerated to prevent H1N1 influenza A virus infection in newly transplanted renal allograft recipient receiving triple immunosuppression without any interaction with tacrolimus level. Oseltamivir was effective for post-exposure prophylaxis of H1N1 in close contact.

Publication types

Case Reports

MeSH terms

Adult
Antiviral Agents / therapeutic use*
Drug Interactions
Fatal Outcome
Female
Humans
Immunosuppressive Agents / therapeutic use*
Influenza A Virus, H1N1 Subtype / drug effects*
Influenza A Virus, H1N1 Subtype / isolation & purification
Influenza, Human / prevention & control*
Influenza, Human / transmission
Kidney Failure, Chronic / complications
Kidney Failure, Chronic / surgery*
Kidney Transplantation*
Male
Middle Aged
Oseltamivir / therapeutic use*
Postoperative Complications / drug therapy
Pregnancy
Reverse Transcriptase Polymerase Chain Reaction
Transplantation, Homologous
Treatment Outcome

Substances

Antiviral Agents
Immunosuppressive Agents
Oseltamivir