As youth and perception of beauty are considered to be of great importance, an increasing number of new cosmeceuticals have been developed in recent years. This article will describe new, evidence-based ingredients against skin-aging; in particular antioxidants (e.g. vitamin C, niacinamide, different polyphenols and flavonoids) and cell regulators (e.g. retinol, different peptides and growth factors. Important parameters for the quality of cosmetics and cosmeceuticals are evidence-based in-vivo and in-vitro efficacy as well as scientifically approved wanted and unwanted effects.