Design, synthesis and structure of novel para-quinones and their antibacterial activity

Chem Biol Drug Des. 2011 Nov;78(5):787-99. doi: 10.1111/j.1747-0285.2011.01187.x. Epub 2011 Sep 15.

Abstract

Eight new para-quinones and one known analogue have been synthesized from p-chloranil. Five have been structurally characterized by single crystal diffraction, and a range of ligand folding is observed. All nine have been tested for their potency towards Gram(+) S. aureus and Gram(-) E. coli. Quinones 3, 6, 7 and 8 have shown activity towards S. aureus and quinones 3 and 8 also show good activity towards E. coli.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents* / chemical synthesis
  • Anti-Bacterial Agents* / chemistry
  • Anti-Bacterial Agents* / pharmacology
  • Crystallography, X-Ray
  • Drug Design*
  • Escherichia coli / drug effects*
  • Microbial Sensitivity Tests
  • Models, Chemical*
  • Molecular Conformation
  • Quinones* / chemical synthesis
  • Quinones* / chemistry
  • Quinones* / pharmacology
  • Staphylococcus aureus / drug effects*

Substances

  • Anti-Bacterial Agents
  • Quinones