Synthesis and benzodiazepine receptor binding of 1H-pyrrolo[2,1-C][1,4]benzothiazines

Farmaco. 1990 Jun;45(6):577-88.

Abstract

The pyrrolo[2,1-c][1,4]benzothiazines 2a-n and the pyrrolo[2,1-c][1,4]thiazine 13 were prepared and tested for their ability to displace specific [3H]diazepam binding from rat brain membranes. Such compounds were found essentially devoid of binding affinity for the benzodiazepine receptor.

MeSH terms

  • Animals
  • Brain / metabolism*
  • Chemical Phenomena
  • Chemistry
  • In Vitro Techniques
  • Pyrroles / chemical synthesis*
  • Pyrroles / metabolism
  • Rats
  • Receptors, GABA-A / metabolism*
  • Thiazines / chemical synthesis*
  • Thiazines / metabolism

Substances

  • Pyrroles
  • Receptors, GABA-A
  • Thiazines