Abstract
In response to decreasing Ca2+ levels in the endoplasmic reticulum, STIM proteins couple with Orai channels in the plasma membrane, leading to Ca2+ influx into the cell. In addition to Ca2+-related endoplasmic reticulum stress, STIM proteins are emerging as general stress sensors that react to multiple stress signals to orchestrate Ca2+ signaling and homeostasis.
MeSH terms
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Biosensing Techniques
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Calcium / metabolism*
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Calcium Channels / genetics
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Calcium Channels / metabolism*
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Calcium Signaling / physiology*
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Endoplasmic Reticulum / metabolism*
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Gene Expression Regulation / physiology
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Membrane Proteins / genetics
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Membrane Proteins / metabolism*
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Stress, Physiological / physiology*
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Temperature
Substances
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Calcium Channels
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Membrane Proteins
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Calcium