Abstract
In the present review, we look back at the recent history of GWAS (genome-wide association studies) in AD (Alzheimer's disease) and integrate the major findings with current knowledge of biological processes and pathways. These topics are essential for the development of animal models, which will be fundamental to our complete understanding of AD.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Alzheimer Disease / etiology
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Alzheimer Disease / genetics*
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Amyloid beta-Peptides / metabolism
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Animals
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Complement System Proteins / genetics
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Disease Models, Animal*
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Endocytosis / genetics
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Genetic Loci
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Genome-Wide Association Study
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Humans
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Inflammation / complications
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Inflammation / genetics
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Lipid Metabolism / genetics
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Polymorphism, Single Nucleotide
Substances
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Amyloid beta-Peptides
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Complement System Proteins