Free radical scavenging, antioxidant enzymes and wound healing activities of leaves extracts from Clerodendrum infortunatum L

K Gouthamchandra; R Mahmood; H Manjunatha

doi:10.1016/j.etap.2010.03.005

Free radical scavenging, antioxidant enzymes and wound healing activities of leaves extracts from Clerodendrum infortunatum L

Environ Toxicol Pharmacol. 2010 Jul;30(1):11-8. doi: 10.1016/j.etap.2010.03.005. Epub 2010 Mar 11.

Authors

K Gouthamchandra¹, R Mahmood, H Manjunatha

Affiliation

¹ Department of P.G. Studies and Research in Biotechnology and Bioinformatics Kuvempu University, Shankaraghatta 577 451, Shimoga, Karnataka, India.

PMID: 21787623
DOI: 10.1016/j.etap.2010.03.005

Abstract

Three successive extracts of Clerodendrum infortunatum L. leaves have been studied for their potential as antioxidants in 1,1-diphenyl-2-picrylhydrazyl (DPPH) model. The scavenging activity of ethanol extract was found to be high when compared to petroleum ether and chloroform extracts. Hence, it was selected to evaluate the beneficial properties using in vitro and in vivo models. The antioxidant and its protective effects against CCl(4) induced oxidative stress in rats were significantly high. Further, to validate the traditional therapeutic claim, wound healing activity of the plant extracts was also carried out. Among the three extracts tested the petroleum ether and ethanol extracts exhibited a significant response. The presence of high antioxidant and pharmacological properties correlates to the total phenolic contents in the plant Clerodendrum infortunatum L.