[Detection and molecular characterization of human parechovirus (HPeV) in children with acute gastroenteritis]

Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2011 Feb;25(1):46-8.
[Article in Chinese]

Abstract

Objective: To study HPeV from stool samples of children with acute gastroenteritis under 5 years old.

Methods: We conducted a real-time PCR to detect HPeV from stool samples and to amply VP1 sequence by nested RT-PCR to identify HPeV type.

Results: The results showed that 27 of 306 (8.82%) children with acute gastroenteritis were infected HPeV. 11 strains were typed. 9 strains HPeV1, both HPeV2 and HPeV4 was 1 strain. HPeV was mostly identified in autumn season with a peak in July. HPeV seemed relevant in children >2 years old. The range of nucleotide identity between all isolated strains with reference strains was 79%-92%.

Conclusion: Epidemiology characteristic of HPeV in Jilin was concordance with that of reports. HPeV3 wasnt detected. It's significant to conduct the large scale and long-term surveillance of HPeV.

Publication types

  • English Abstract

MeSH terms

  • Acute Disease
  • Child, Preschool
  • Female
  • Gastroenteritis / epidemiology
  • Gastroenteritis / virology*
  • Humans
  • Infant
  • Male
  • Parechovirus / classification
  • Parechovirus / genetics
  • Parechovirus / isolation & purification*
  • Phylogeny