New chiral cyclooctatriene-based polycyclic architectures

Org Lett. 2011 Aug 19;13(16):4450-3. doi: 10.1021/ol201804h. Epub 2011 Jul 26.

Abstract

The synthesis and properties of new chiral polycyclic architectures that display both helicity and a saddle-type shape are described. The enantiomers have been separated, and their absolute configuration was determined by VCD and ECD. The unprecedented molecular architecture is based on a cyclooctatriene core surrounded by an association of benzo[c]fluorene and ortho-phenylene units.