Yojironins E-I, prenylated acylphloroglucinols from Hypericum yojiroanum

Naonobu Tanaka; Takuji Mamemura; Azusa Shibazaki; Tohru Gonoi; Jun'ichi Kobayashi

doi:10.1016/j.bmcl.2011.07.004

Yojironins E-I, prenylated acylphloroglucinols from Hypericum yojiroanum

Bioorg Med Chem Lett. 2011 Sep 15;21(18):5393-7. doi: 10.1016/j.bmcl.2011.07.004. Epub 2011 Jul 13.

Authors

Naonobu Tanaka¹, Takuji Mamemura, Azusa Shibazaki, Tohru Gonoi, Jun'ichi Kobayashi

Affiliation

¹ Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.

PMID: 21802287
DOI: 10.1016/j.bmcl.2011.07.004

Abstract

Five new prenylated acylphloroglucinols, yojironins E-Ι (1-5), were isolated from the whole plants of Hypericum yojiroanum. Their structures were elucidated by spectroscopic data. Yojironin E (1) exhibited antimicrobial activity against Aspergillus niger, Candida albicans, Cryptococcus neoformans, and Trichophyton mentagrophytes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antifungal Agents / chemistry
Antifungal Agents / isolation & purification
Antifungal Agents / pharmacology*
Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification
Antineoplastic Agents / pharmacology
Aspergillus niger / drug effects
Candida albicans / drug effects
Cell Line, Tumor
Cryptococcus neoformans / drug effects
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Humans
Hypericum / chemistry*
Magnetic Resonance Spectroscopy
Mice
Microbial Sensitivity Tests
Models, Molecular
Molecular Conformation
Phloroglucinol / analogs & derivatives*
Phloroglucinol / chemistry
Phloroglucinol / pharmacology*
Stereoisomerism
Structure-Activity Relationship
Trichophyton / drug effects

Substances

Antifungal Agents
Antineoplastic Agents
Phloroglucinol