An efficient microwave assisted synthesis of novel class of Rhodanine derivatives as potential HIV-1 and JSP-1 inhibitors

Sukanta Kamila; Haribabu Ankati; Edward R Biehl

doi:10.1016/j.tetlet.2011.05.114

An efficient microwave assisted synthesis of novel class of Rhodanine derivatives as potential HIV-1 and JSP-1 inhibitors

Tetrahedron Lett. 2011 Aug 24;52(34):4375-4377. doi: 10.1016/j.tetlet.2011.05.114.

Authors

Sukanta Kamila¹, Haribabu Ankati, Edward R Biehl

Affiliation

¹ Southern Methodist University, Department of, Chemistry, Dallas, TX, 75275.

Abstract

(Z)-5-(2-(1H-Indol-3-yl)-2-oxoethylidene)-3-phenyl-2-thioxothiazolidin-4-one (7a-q) derivatives have been synthesized by the condensation reaction of 3-phenyl-2-thioxothiazolidin-4-ones (3a-h) with suitably substituted 2-(1H-indol-3-yl)-2-oxoacetaldehyde (6a-d) under microwave condition. The thioxothiazolidine-4-ones were prepared from corresponding aromatic amines (1a-e) and di-(carboxymethyl)-trithiocarbonyl (2). The aldehydes (6a-h) were synthesized from the corresponding acidchlorides (5a-d) using HSnBu(3).

Abstract

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