Curcumin derivatives as new ligands of Aβ peptides

Cristina Airoldi; Cristiano Zona; Erika Sironi; Laura Colombo; Massimo Messa; Dario Aurilia; Maria Gregori; Massimo Masserini; Mario Salmona; Francesco Nicotra; Barbara La Ferla

doi:10.1016/j.jbiotec.2011.07.021

Curcumin derivatives as new ligands of Aβ peptides

J Biotechnol. 2011 Dec 20;156(4):317-24. doi: 10.1016/j.jbiotec.2011.07.021. Epub 2011 Jul 22.

Authors

Cristina Airoldi¹, Cristiano Zona, Erika Sironi, Laura Colombo, Massimo Messa, Dario Aurilia, Maria Gregori, Massimo Masserini, Mario Salmona, Francesco Nicotra, Barbara La Ferla

Affiliation

¹ Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, Milan, Italy. [email protected]

PMID: 21807037
DOI: 10.1016/j.jbiotec.2011.07.021

Abstract

Curcumin derivatives with high chemical stability, improved solubility and carrying a functionalized appendage for the linkage to other entities, have been synthesized in a straightforward manner. All compounds retained Curcumin ability to bind Aβ peptide oligomers without inducing their aggregation. Moreover all Curcumin derivatives were able to stain very efficiently Aβ deposits.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alzheimer Disease
Amyloid beta-Peptides / chemistry
Amyloid beta-Peptides / genetics
Amyloid beta-Peptides / metabolism*
Animals
Brain Chemistry
Curcumin / analogs & derivatives*
Curcumin / chemistry
Curcumin / metabolism
Histocytochemistry
Humans
Mice
Mice, Transgenic
Molecular Dynamics Simulation
Nuclear Magnetic Resonance, Biomolecular
Peptide Fragments / chemistry
Peptide Fragments / metabolism*
Protein Binding
Solubility

Substances

Amyloid beta-Peptides
Peptide Fragments
Curcumin