Determination of photostability and photodegradation products of indomethacin in aqueous media

Fabio Temussi; Flavio Cermola; Marina Dellagreca; M Rosaria Iesce; Monica Passananti; Lucio Previtera; Armando Zarrelli

doi:10.1016/j.jpba.2011.07.005

Determination of photostability and photodegradation products of indomethacin in aqueous media

J Pharm Biomed Anal. 2011 Dec 5;56(4):678-83. doi: 10.1016/j.jpba.2011.07.005. Epub 2011 Jul 12.

Authors

Fabio Temussi¹, Flavio Cermola, Marina Dellagreca, M Rosaria Iesce, Monica Passananti, Lucio Previtera, Armando Zarrelli

Affiliation

¹ UDR Napoli 4 (Consorzio INCA), IC-REACH Dipartimento di Chimica Organica e Biochimica, Università Federico II, Complesso Universitario Monte S. Angelo, Via Cinthia 4, I-80126 Napoli, Italy.

PMID: 21807472
DOI: 10.1016/j.jpba.2011.07.005

Abstract

Photochemical behaviour of indomethacin in aqueous media at 254nm, 310nm and sunlight was studied by HPLC. The drug exhibited a similar behaviour in all the irradiation experiments affording eight photoproducts that were separated and identified. The main photochemical routes are suggested to proceed via decarboxylation, followed by oxygenation to give an alcohol and an aldehyde and/or by solvent trapping to produce the alcohol. Photoinduced hydrolysis of CO-N bond and oxidative C2-C3 bond breakage also occur.

MeSH terms

Anti-Inflammatory Agents, Non-Steroidal / analysis*
Anti-Inflammatory Agents, Non-Steroidal / chemistry
Anti-Inflammatory Agents, Non-Steroidal / metabolism
Drug Stability
Humans
Hydrolysis
Indomethacin / analysis*
Indomethacin / chemistry
Indomethacin / metabolism
Oxidation-Reduction
Pharmacokinetics
Photolysis*
Photosensitivity Disorders / metabolism
Solvents
Sunlight
Ultraviolet Rays
Water Pollutants, Chemical / analysis
Water Pollutants, Chemical / chemistry
Water Pollutants, Chemical / metabolism

Substances

Anti-Inflammatory Agents, Non-Steroidal
Solvents
Water Pollutants, Chemical
Indomethacin