Abstract
Obovatol derivatives were synthesized and evaluated for anti-platelet activity. Three derivatives (1, 2, 4i) displayed equipotent activity to obovatol in arachidonic acid-induced platelet aggregation. An initial SAR study revealed that the introduction of alkoxy group in B ring could enhance inhibitory activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alcohols / chemistry
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Arachidonic Acid / antagonists & inhibitors
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Arachidonic Acid / pharmacology
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Biphenyl Compounds / chemistry
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Biphenyl Compounds / pharmacology*
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Collagen / pharmacology
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Dose-Response Relationship, Drug
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Phenyl Ethers / chemistry
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Phenyl Ethers / pharmacology*
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Platelet Activation / drug effects*
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Platelet Aggregation / drug effects*
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Platelet Aggregation Inhibitors / chemical synthesis
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Platelet Aggregation Inhibitors / chemistry
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Platelet Aggregation Inhibitors / pharmacology*
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Rabbits
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Structure-Activity Relationship
Substances
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Alcohols
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Antineoplastic Agents
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Biphenyl Compounds
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Phenyl Ethers
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Platelet Aggregation Inhibitors
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alkoxyl radical
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Arachidonic Acid
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obovatol
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Collagen