Gene editing in stem cells hits the target

Ho Won Kim; Clive Niels Svendsen

doi:10.1016/j.stem.2011.07.011

Gene editing in stem cells hits the target

Cell Stem Cell. 2011 Aug 5;9(2):93-4. doi: 10.1016/j.stem.2011.07.011.

Authors

Ho Won Kim¹, Clive Niels Svendsen

Affiliation

¹ The Regenerative Medicine Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA.

PMID: 21816359
DOI: 10.1016/j.stem.2011.07.011

Abstract

Two recent reports describe promising, highly efficient methods to modify genes in pluripotent stem cells using zinc finger nuclease (ZFN)-mediated (Soldner et al., 2011) or helper-dependent adenovirus (HDAdV)-mediated (Liu et al., 2011b) gene modification. These technical developments will have far ranging effects on the rapidly growing field of regenerative medicine.

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