Abstract
Several quinonoid and phenazine compounds were synthesized in moderate to high yields and showed activity against H(37)Rv, rifampicin and isoniazid-resistance strains of Mycobacterium tuberculosis. The cytotoxity of the compounds were evaluated against human peripheral blood mononuclear cells (PBMC) and these substances emerge as promising antitubercular prototypes.
Copyright © 2011 Elsevier Masson SAS. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antitubercular Agents / chemical synthesis*
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Antitubercular Agents / chemistry
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Antitubercular Agents / pharmacology*
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Cells, Cultured
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Drug Resistance, Microbial
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Isoniazid / pharmacology
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Models, Molecular
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Mycobacterium tuberculosis / drug effects*
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Phenazines / chemical synthesis*
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Phenazines / chemistry
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Phenazines / pharmacology
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Quinones / chemical synthesis*
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Quinones / chemistry
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Quinones / pharmacology
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Rifampin / pharmacology
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Spectrometry, Mass, Electrospray Ionization
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Spectrophotometry, Infrared
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X-Ray Diffraction
Substances
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Antitubercular Agents
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Phenazines
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Quinones
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Isoniazid
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Rifampin