Abstract
MicroRNAs (miRNAs) are an abundant class of evolutionarily conserved, small, non-coding RNAs that post-transcriptionally regulate expression of their target genes. Emerging evidence indicates that miRNAs are important regulators that control the development, differentiation and function of different immune cells. Both CD4(+)CD25(+)Foxp3(+) regulatory T (Treg) cells and invariant natural killer T (iNKT) cells are critical for immune homeostasis and play a pivotal role in the maintenance of self-tolerance and immunity. Here, we review the important roles of miRNAs in the development and function of iNKT and Treg cells.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antigens, CD / immunology
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Cell Differentiation / genetics
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Cell Differentiation / immunology
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DEAD-box RNA Helicases / genetics
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DEAD-box RNA Helicases / immunology
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DEAD-box RNA Helicases / metabolism
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Flow Cytometry
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Humans
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Immunity, Innate* / genetics
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Mice
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Mice, Knockout
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MicroRNAs / genetics
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MicroRNAs / immunology*
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MicroRNAs / metabolism
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Natural Killer T-Cells / immunology*
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Natural Killer T-Cells / metabolism
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RNA Processing, Post-Transcriptional / genetics
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RNA Processing, Post-Transcriptional / immunology*
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RNA Stability / immunology*
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RNA, Messenger / biosynthesis
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Ribonuclease III / genetics
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Ribonuclease III / immunology
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Ribonuclease III / metabolism
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Self Tolerance / immunology
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T-Lymphocytes, Regulatory / immunology*
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T-Lymphocytes, Regulatory / metabolism
Substances
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Antigens, CD
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MicroRNAs
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RNA, Messenger
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Dicer1 protein, mouse
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Drosha protein, mouse
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Ribonuclease III
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DEAD-box RNA Helicases