Abstract
Innate immunity is the front line of self-defense against microbial infection. After searching for natural substances that regulate innate immunity using an ex vivo Drosophila culture system, we identified a novel dimeric chromanone, gonytolide A, as an innate immune promoter from the fungus Gonytrichum sp. along with gonytolides B and C. Gonytolide A also increased TNF-α-stimulated production of IL-8 in human umbilical vein endothelial cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Survival / drug effects
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Crystallography, X-Ray
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Cytokines / biosynthesis
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Cytokines / immunology
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Dimerization
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Drosophila / immunology
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Endothelial Cells / drug effects
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Endothelial Cells / immunology
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Humans
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Immunity, Innate / immunology*
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Immunosuppressive Agents / immunology*
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Immunosuppressive Agents / isolation & purification*
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Immunosuppressive Agents / pharmacology
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Mitosporic Fungi / chemistry*
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Mitosporic Fungi / immunology
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Models, Molecular
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Molecular Structure
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Stereoisomerism
Substances
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Cytokines
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Immunosuppressive Agents