Abstract
The synthesis of gaultherin (1) and its analogs was carried out to provide 11 glycosides under phase-transfer catalytic conditions. The activities of all synthesized compounds were evaluated by nitric oxide production inhibitory assay in vitro. Methyl 2-O-(4-O-β-d-galactopyranosyl)-β-d-glucopyranosylbenzoate (5f) showed significantly anti-nociceptive and anti-inflammatory effects by the evaluation in vivo. Structure-activity relationships within these compounds were discussed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Analgesics / chemical synthesis*
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Analgesics / chemistry
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Analgesics / pharmacology*
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Animals
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Anti-Inflammatory Agents / chemical synthesis*
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / pharmacology*
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Croton Oil / pharmacology
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Disaccharides / chemical synthesis*
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Disaccharides / chemistry
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Disaccharides / pharmacology*
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Edema / chemically induced
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Edema / drug therapy
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Macrophages / drug effects
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Mice
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Nitric Oxide / biosynthesis
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Salicylates / chemical synthesis*
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Salicylates / chemistry
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Salicylates / pharmacology*
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Stereoisomerism
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Structure-Activity Relationship
Substances
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Analgesics
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Anti-Inflammatory Agents
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Disaccharides
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Salicylates
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methyl 2-O-(4-O-beta-D-galactopyranosyl)-beta-D-glucopyranosylbenzoate
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Nitric Oxide
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2-((6-O-beta-D-Xylopyranosyl-beta-D-glucopyranosyl)oxy) benzoic acid methyl ester
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Croton Oil