Diagnostics and treatment of hepatobiliary pathologies are known to be the indispensable prerequisites for the successful compensation of diabetes mellitus (DM). The present study revealed disturbances of bile-producing and bile-secreting functions of the liver in all the examined patients with DM. Moreover, the biochemical composition of bile and the ratio of its major components proved to be pathologically altered. The treatment program based at the Metallurg health resort including consumption of the local mineral water resulted in the significant improvement of the hepatic secretory function and normalization of motor-tonic activity of the bile-secreting system in patients presenting with type 2 diabetes mellitus at the stage of noncalculous cholecystitis.