[High-grade small bowel angiosarcoma associated with angiosarcomatosis: a case report]

Sanae Chahbouni; Raphaëlle Barnoud; Emmanuel Watkin; Mojgan Devouassoux-Shisheboran

doi:10.1016/j.annpat.2011.04.002

[High-grade small bowel angiosarcoma associated with angiosarcomatosis: a case report]

Ann Pathol. 2011 Aug;31(4):303-6. doi: 10.1016/j.annpat.2011.04.002. Epub 2011 Jul 8.

[Article in French]

Authors

Sanae Chahbouni¹, Raphaëlle Barnoud, Emmanuel Watkin, Mojgan Devouassoux-Shisheboran

Affiliation

¹ Service d'anatomie et cytologie pathologiques, hôpital de la Croix-Rousse, 103, grande rue de la Croix-Rousse, 69317 Lyon cedex 04, France.

PMID: 21839357
DOI: 10.1016/j.annpat.2011.04.002

Abstract

Angiosarcoma is a rare soft-tissue neoplasm occurring most often in the skin and the subcutaneous tissues and very rarely in the gastrointestinal tract. We report a case of a 25-year-old woman who presented with a small intestinal angiosarcoma associated with angiosarcomatosis. The diagnosis was established on surgical intestinal resection, that showed a high-grade angiosarcoma with epithelioid component and foci of agressive form of hemangioendothelioma. Immunohistochemical study revealed tumour cell positivity with endothelial markers CD31 and factor VIII whereas CD34 and epithelial markers were negative. The tumour displayed KIT (CD117) immunoreactivity without KIT or PDGFRA mutation on molecular analysis. Clinical and pathological features as well as differential diagnosis of this rare entity in gastrointestinal tract are discussed.

Publication types

Case Reports
English Abstract

MeSH terms

Adult
Antibiotics, Antineoplastic / therapeutic use
Biomarkers, Tumor / analysis
Combined Modality Therapy
Diagnostic Errors*
Doxorubicin / therapeutic use
Fatal Outcome
Female
Hemangioendothelioma, Epithelioid / chemistry
Hemangioendothelioma, Epithelioid / diagnosis*
Hemangioendothelioma, Epithelioid / drug therapy
Hemangioendothelioma, Epithelioid / pathology
Hemangioendothelioma, Epithelioid / surgery
Hemangiosarcoma / chemistry
Hemangiosarcoma / diagnosis
Hemangiosarcoma / drug therapy
Hemangiosarcoma / pathology
Hemangiosarcoma / secondary*
Hemangiosarcoma / surgery
Humans
Ileal Neoplasms / chemistry
Ileal Neoplasms / diagnosis*
Ileal Neoplasms / drug therapy
Ileal Neoplasms / pathology
Ileal Neoplasms / surgery
Mesentery / pathology*
Neoplasms, Multiple Primary / chemistry
Neoplasms, Multiple Primary / diagnosis*
Neoplasms, Multiple Primary / drug therapy
Neoplasms, Multiple Primary / pathology
Neoplasms, Multiple Primary / surgery
Peritoneal Neoplasms / chemistry
Peritoneal Neoplasms / diagnosis
Peritoneal Neoplasms / drug therapy
Peritoneal Neoplasms / pathology
Peritoneal Neoplasms / secondary*
Peritoneal Neoplasms / surgery
Peritonitis, Tuberculous / diagnosis

Substances

Antibiotics, Antineoplastic
Biomarkers, Tumor
Doxorubicin