Abstract
A novel macrocyclic lactone (1) was isolated from the fermentation broth of Streptomycesmicroflavus neau3, and the structure was elucidated by extensive spectroscopic analysis. Compound 1 showed high acaricidal activity against adult mites (IC(50)=11.1 μg mL(-1)), and nematocidal activity against Caenorhabditis elegans (IC(50)=17.4 μg mL(-1)), especially the acaricidal activity against mite eggs with an IC(50) of 37.1 μg mL(-1), which was relative higher than that of the commercial acaricide and nematocide milbemycins A(3)/A(4).
Copyright © 2011 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acaricides / chemistry
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Acaricides / isolation & purification
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Acaricides / pharmacology*
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Animals
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Antinematodal Agents / chemistry
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Antinematodal Agents / isolation & purification
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Antinematodal Agents / pharmacology*
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Caenorhabditis elegans / drug effects*
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Dose-Response Relationship, Drug
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Drug Evaluation, Preclinical
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Fermentation
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Insecticides / chemistry
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Insecticides / isolation & purification
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Insecticides / pharmacology
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Lactones / chemistry
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Lactones / isolation & purification
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Lactones / pharmacology*
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Macrocyclic Compounds / chemistry
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Macrocyclic Compounds / isolation & purification
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Macrocyclic Compounds / pharmacology*
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Mites / drug effects*
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Molecular Conformation
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Stereoisomerism
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Streptomyces / chemistry
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Streptomyces / metabolism
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Structure-Activity Relationship
Substances
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Acaricides
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Antinematodal Agents
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Insecticides
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Lactones
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Macrocyclic Compounds